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Discrepancies Between Observed and Self-Classified Race in Spirometry Interpretation: Insights from the Canadian Longitudinal Study on Aging

2025· article· W4416639288 on OpenAlexaffabout
Amin Adibi, Emily Brigham, Chris Carlsten, Peter Loewen, Don D. Sin, Mohsen Sadatsafavi

Bibliographic record

VenueEpidemiology · 2025
Typearticle
Language
FieldMedicine
TopicChronic Obstructive Pulmonary Disease (COPD) Research
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsRace (biology)SpirometryLongitudinal studyLogistic regressionLung functionRacial differencesDifferential effectsRace and health

Abstract

fetched live from OpenAlex

<bold>Background:</bold> An underexplored issue with race-specific lung function reference equations is the inaccuracies in collecting race data. We evaluated disproportionate impact of these inaccuracies on visible minorities. <bold>Methods:</bold> Using 2011-2021 data from the Canadian Longitudinal Study on Aging, we compared patients’ self-classified race with race observed by spirometry lab technicians and evaluated impacts of racial misclassification on FEV<sub>1</sub> Z-scores calculated with GLI-2012 equations. We used survey logistic regression to study the association between self-classified race and racial misclassification, controlling for age, sex, province, and social standing. <bold>Results:</bold> Among 21,319 individuals with high-quality spirometry, self-classified and observed race varied in 1% of White participants, while it ranged from 19% to 77% among visible minority groups (Figure 1) with differential impact on FEV<sub>1</sub> Z-scores (Figure 2). <bold>Conclusions:</bold> Racial misclassifications can make race-specific reference equations disproportionately less accurate for many visible minority groups. <fig><object-id>erj;66/suppl_69/PA3720/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig> <fig><object-id>erj;66/suppl_69/PA3720/F2</object-id><object-id>F2</object-id><object-id>F2</object-id><graphic></graphic></fig>

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.010
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.222
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.010
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.125
GPT teacher head0.388
Teacher spread0.263 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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