Balancing rice blast resistance and growth through suppression of the E3 ubiquitin ligase OsRING80
Bibliographic record
Abstract
In crop plants, there is often a trade-off between growth and defense; modulating the balance is crucial for effective crop improvement. In rice (Oryza sativa), the DENSE AND ERECT PANICLE 2 (DEP2) mutant shows altered phenotypes such as a more vertical leaf angle, erect panicles, small and round grains, slightly lower thousand-grain weight, and dwarfism. Here, we determined that loss of DEP2 function enhances resistance to the rice blast fungus Magnaporthe oryzae. We established that DEP2 interacts with the E3 ubiquitin ligase OsRING80, which ubiquitinates DEP2 and promotes its degradation via the 26S proteasome pathway. Interestingly, the transcriptional level of OsRING80 was lower in dep2 mutant lines, suggesting feedback regulation of OsRING80 by DEP2. Remarkably, knocking out OsRING80 through CRISPR/Cas9-mediated gene editing resulted in greater resistance to M. oryzae without compromising plant growth. These findings reveal that OsRING80 plays a crucial role in balancing plant immunity and growth by targeting DEP2; they also provide a valuable candidate gene for developing improved rice cultivars with both disease resistance and optimal agronomic traits.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".