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Record W4416735560 · doi:10.1186/s12911-025-03253-8

Eye-XAI: an explainable artificial intelligence approach for eye disease detection using symptom analysis

2025· article· en· W4416735560 on OpenAlexaff
Ahmed Al Marouf, Md Mozaharul Mottalib, Sadia Sobhana Ridi, Omar Jafarullah, Jon Rokne, Reda Alhajj

Bibliographic record

VenueBMC Medical Informatics and Decision Making · 2025
Typearticle
Languageen
FieldMedicine
TopicRetinal Imaging and Analysis
Canadian institutionsUniversity of Calgary
Fundersnot available
KeywordsInterpretabilityTransparency (behavior)Health informaticsDiseaseQuality (philosophy)Health care

Abstract

fetched live from OpenAlex

The early and accurate detection of eye diseases play a pivotal role in preventing vision loss and improving patients’ quality of life. It is therefore important to search for methods for improving this detection. It turns out that Artificial Intelligence (AI) has shown great promise for the detection task. However, AI models are often opaque and complex and as a result there has been a slow adoption for these models in clinical settings. In this paper Eye-XAI is introduced which provides an effective approach to the detection combining Explainable Artificial Intelligence (XAI) techniques with symptom analysis to enhance the transparency and interpretability of eye disease detection models. Our results demonstrate that Eye-XAI not only achieves high accuracy (99.11%) for eye disease detection but also provides transparent and interpretable insights into the diagnostic process. The adoption of Eye-XAI can therefore significantly enhance the early detection and management of eye diseases while empowering clinicians with a deeper understanding of its AI-based diagnostic recommendations. Furthermore, this approach promotes patient engagement by facilitating communication and trust between patients and their healthcare providers. Eye-XAI represents a major step towards the integration of XAI in ophthalmology, unlocking new possibilities for improved eye disease diagnosis and treatment.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.965
Threshold uncertainty score0.525

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.054
GPT teacher head0.398
Teacher spread0.345 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations2
Published2025
Admission routes1
Has abstractyes

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