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Record W4416758977 · doi:10.6026/973206300214241

Cardiovascular and neurovascular complications in systemic lupus Erythematosus: A cross-sectional study of subclinical atherosclerosis and cognitive dysfunction

2025· article· en· W4416758977 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

aboutThe title or abstract carries a Canadian signal from the geographic lexicon.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueBioinformation · 2025
Typearticle
Languageen
FieldMedicine
TopicSystemic Lupus Erythematosus Research
Canadian institutionsnot available
Fundersnot available
KeywordsSubclinical infectionNeurovascular bundleCognitionConcomitantSystemic lupus erythematosusEndothelial dysfunctionAntiphospholipid syndromeDisease

Abstract

fetched live from OpenAlex

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune condition that has increase appreciated cardiovascular and neurovascular complications. This report presents a cross-sectional study of 100 SLE patients (18-55 years) who were evaluated for the prevalence and relationship of subclinical atherosclerosis and cognitive dysfunction. Subclinical atherosclerosis was measured by carotid intima-media thickness (CIMT) and cognition was measured by scoring the Montreal Cognitive Assessment (MoCA). The study found that 36% of participants had subclinical atherosclerosis, while 42% had cognitive impairment. Both subclinical atherosclerosis and cognitive dysfunction were associated with longer disease duration, corticosteroid exposure, higher SLEDAI scores and the presence of antiphospholipid antibodies. Data shows the high prevalence of concomitant vascular and cognitive dysfunction in SLE patients and the need for early screening for both outcomes in a non-invasive manner.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.014
Threshold uncertainty score0.498

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.035
GPT teacher head0.319
Teacher spread0.284 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it