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Record W4416758977 · doi:10.6026/973206300214241

Cardiovascular and neurovascular complications in systemic lupus Erythematosus: A cross-sectional study of subclinical atherosclerosis and cognitive dysfunction

2025· article· en· W4416758977 on OpenAlexaboutno aff
Abberamiy Pushparaj

Bibliographic record

VenueBioinformation · 2025
Typearticle
Languageen
FieldMedicine
TopicSystemic Lupus Erythematosus Research
Canadian institutionsnot available
Fundersnot available
KeywordsSubclinical infectionNeurovascular bundleCognitionConcomitantSystemic lupus erythematosusEndothelial dysfunctionAntiphospholipid syndromeDisease

Abstract

fetched live from OpenAlex

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune condition that has increase appreciated cardiovascular and neurovascular complications. This report presents a cross-sectional study of 100 SLE patients (18-55 years) who were evaluated for the prevalence and relationship of subclinical atherosclerosis and cognitive dysfunction. Subclinical atherosclerosis was measured by carotid intima-media thickness (CIMT) and cognition was measured by scoring the Montreal Cognitive Assessment (MoCA). The study found that 36% of participants had subclinical atherosclerosis, while 42% had cognitive impairment. Both subclinical atherosclerosis and cognitive dysfunction were associated with longer disease duration, corticosteroid exposure, higher SLEDAI scores and the presence of antiphospholipid antibodies. Data shows the high prevalence of concomitant vascular and cognitive dysfunction in SLE patients and the need for early screening for both outcomes in a non-invasive manner.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.035
GPT teacher head0.319
Teacher spread0.284 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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