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Record W4416763469 · doi:10.1111/jvh.70109

Pharmacist‐Led Hepatitis C Diagnosis and Rapid Management—In Community ( <scp>PHARM</scp> ‐C): Results From a Phase <scp>IV</scp> Nonblinded Randomised Controlled Trial

2025· article· en· W4416763469 on OpenAlexafffund
Mia J. Biondi, Camelia Capraru, B. L. Harper, P. P. S. Gill, Cheryl Dale, Matthew Boutrous, Vincent Lam, David Morkos, Bethany Barber, Mediongo‐Abasi Usoro, Andrew Mendlowitz, Hemant Shah, Guillaume Fontaine, Bettina E. Hansen, Jordan J. Feld

Bibliographic record

VenueJournal of Viral Hepatitis · 2025
Typearticle
Languageen
FieldMedicine
TopicHepatitis C virus research
Canadian institutionsMcGill UniversityMaple Leaf Medical ClinicToronto Liver CentreYork University
FundersAbbVie Canada
KeywordsRandomized controlled trialHepatitis C virusHepatitis CStandard of careHepacivirusClinical trialPhase (matter)

Abstract

fetched live from OpenAlex

This was a nonblinded randomised controlled trial comparing pharmacist-led hepatitis C virus (HCV) treatment in the community, to tertiary care hepatology. Of 34 antibody-positive individuals, 28 completed a rapid HCV RNA test in the pharmacy. The study was terminated after randomising 11 participants over 15 months (recruitment continued until ~27 months), as a result of feasibility concerns of pharmacist-led care, and here we highlight important lessons learned to consider for future efforts.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.012
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow), Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.445
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0050.012
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0030.001
Bibliometrics0.0020.001
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0010.000
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.040
GPT teacher head0.369
Teacher spread0.329 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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