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Record W4416776633 · doi:10.1177/01926233251386855

Hot Topics, Future Directions, and Challenges Faced in Toxicologic Neuropathology

2025· article· en· W4416776633 on OpenAlexaff
Alys Bradley, Elizabeth J. Galbreath, Félix Goulet, Kristel Kegler, Lisa G. Lanigan, Ingrid D. Pardo, Alok Sharma, Michael Staup, Jimmy Tran, Katrin Weber, Klaus Weber, Aleksandra Żuraw

Bibliographic record

VenueToxicologic Pathology · 2025
Typearticle
Languageen
FieldImmunology and Microbiology
TopicImmunotoxicology and immune responses
Canadian institutionsCanadian Nuclear Laboratories
Fundersnot available
KeywordsNeuropathologySession (web analytics)Focused ultrasoundCentral nervous systemDilemma

Abstract

fetched live from OpenAlex

In this half-day session of the Society of Toxicologic Pathology Annual meeting, we focused on hot topics, future directions, and challenges faced in toxicologic neuropathology. The panel of speakers addressed issues with direct delivery of agents to the brain, the dilemma of cervical dorsal root ganglia collection, and new approaches using digital pathology techniques for assessment of the nervous system.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.024
metaresearch head score (Gemma)0.013
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.024
Threshold uncertainty score0.128

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0240.013
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0020.002
Science and technology studies0.0030.004
Scholarly communication0.0080.009
Open science0.0020.005
Research integrity0.0110.013
Insufficient payload (model declined to judge)0.0100.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.258
Teacher spread0.238 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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