Glial adherens junction proteins act with SAX-7/L1CAM to promote dendrite extension in <i>C. elegans</i>
Bibliographic record
Abstract
Adherens junctions (AJs) stabilize cell contacts by coupling adhesion molecules to the cytoskeleton. AJ proteins have been studied extensively in epithelia, but less is known about their roles in other cell types. Here, we describe a role for AJ proteins in C. elegans glia. Previously, we showed that C. elegans glia use the adhesion molecule SAX-7/L1CAM to anchor the dendritic endings of URX and BAG sensory neurons at the nose during embryo elongation, allowing their dendrites to stretch to their full lengths. Using cell-specific rescue and depletion experiments, we show that the AJ proteins MAGI-1 and HMR-1/Cadherin also act in glia to promote URX and BAG dendrite extension. MAGI-1 is a multi-PDZ domain protein that can simultaneously interact with PDZ-binding (PB) motifs in SAX-7 and HMP-2/β-catenin thus potentially bridging SAX-7 to the cadherin-catenin complex. The SAX-7 PB motif also binds AFD-1/afadin. Double-mutant analyses indicate that many of these players act redundantly, consistent with parallel interactions among them. As MAGI-1, HMR-1 and AFD-1 are all found in epithelial AJs, we propose that an AJ-like complex in glia promotes dendrite extension.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".