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Record W4416791925 · doi:10.1101/2025.11.26.690863

Distributed activity in the human posterior putamen distinguishes goal-directed from habitual control

2025· preprint· en· W4416791925 on OpenAlexaff
Amogh Johri, Lisa Marieke Kluen, Rani Gera, Vincent Man, Omar D. Pérez, Julia Pia Simon, Wen Long Ding, Aniek Fransen, Scarlet Cho, Sarah Oh, Jeffrey Cockburn, Jamie D. Feusner, Reza Tadayonnejad, J.V. O’Doherty

Bibliographic record

VenuebioRxiv (Cold Spring Harbor Laboratory) · 2025
Typepreprint
Languageen
FieldNeuroscience
TopicNeural and Behavioral Psychology Studies
Canadian institutionsUniversity of TorontoCentre for Addiction and Mental Health
FundersNational Institute of Mental HealthCalifornia Institute of Technology
KeywordsPutamenContrast (vision)Neural activityThalamusMultivariate statisticsMedical diagnosis

Abstract

fetched live from OpenAlex

How do some individuals rapidly form habits while others maintain flexible, goal-directed control? Using multivariate fMRI decoding in 199 participants, we show that distributed neural activity patterns in the left posterior putamen during initial learning predict individual behavioral strategy on a subsequent outcome devaluation test. This prediction generalized across two independent cohorts of healthy adults and psychiatric patients with heterogeneous diagnoses and was anatomically specific to the posterior putamen. Critically, predictive neural signatures were present during training, before strategy expression after devaluation, enabling prospective classification of habitual versus goal-directed behavior. These findings demonstrate that stable individual differences in behavioral control are reflected in circumscribed brain activity during learning, highlighting the posterior putamen as a candidate neural marker of habit propensity with potential clinical relevance.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.048
GPT teacher head0.301
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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