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Record W4416840811 · doi:10.1007/s10067-025-07766-5

A clinical care pathway for managing pregnancy in patients with inflammatory arthritis

2025· article· en· W4416840811 on OpenAlexaffabout
Neda Amiri, Carl A. Laskin, Viktoria Pavlova, Sarah M. Troster

Bibliographic record

VenueClinical Rheumatology · 2025
Typearticle
Languageen
FieldMedicine
TopicPregnancy and Medication Impact
Canadian institutionsUniversity of AlbertaMcMaster UniversityCReATe Fertility CentreUniversity of TorontoArup Group (Canada)Arthritis Research Centre of CanadaResearch CanadaUniversity of British Columbia
FundersUCB Pharma
KeywordsPregnancyBreastfeedingContext (archaeology)Clinical pathwayPostpartum periodDiseaseMultidisciplinary approachPostnatal CareDisease management

Abstract

fetched live from OpenAlex

Inflammatory arthritis (IA) disproportionately affects women and is particularly concerning in those of childbearing age, where unique considerations are required in their management. Existing practice guidelines provide recommendations on managing IA before, during, and after pregnancy. However, there is a lack of Canadian clinical resources to support shared decision-making between clinicians and patients with IA. A comprehensive care plan for women of childbearing age with IA should include preconception counselling, a 40-week pregnancy plan, and postpartum care. Preconception counselling should address contraception to reduce the risk of unplanned pregnancy, as well as the bidirectional impact of disease on pregnancy outcomes. The 40-week pregnancy plan includes monitoring disease activity, assessing medication safety, and planning delivery. The postpartum care plan should emphasize medication management, particularly in the context of breastfeeding and vaccinations for infants exposed to biologic medications in utero. The goal of this clinical care pathway is to provide a resource for managing patients with IA who are contemplating pregnancy, are pregnant, or are in the postpartum period. Key Points • Managing women of childbearing age with inflammatory arthritis (IA) requires a unique set of considerations. • There is a lack of Canadian clinical resources to guide the management of women of childbearing age with IA. • This clinical care pathway is intended as a resource for multidisciplinary teams managing patients with IA who are contemplating pregnancy, are pregnant, or are in the postpartum period. • The proposed care pathway includes preconception counselling, a 40-week pregnancy plan, and postpartum care for women of childbearing age with IA.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.271
Threshold uncertainty score0.581

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.362
Teacher spread0.343 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes2
Has abstractyes

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