Supramolecular host–guest modulated thermally activated delayed fluorescence for photodynamic therapy
Bibliographic record
Abstract
Supramolecular host-guest chemistry can tune the photophysical behavior of organic emitters by confining them within well-defined nanoscale environments. Here we report a straightforward strategy to modulate the thermally activated delayed fluorescence (TADF) properties of organic emitters in aqueous media through complexation with the macrocyclic host cucurbit[7]uril (CB[7]). Upon formation of the TADF-CB[7] complex, the photoluminescence quantum yield is enhanced due to the suppression of non-radiative decay pathways within the rigid host cavity. Furthermore, host-guest encapsulation was found to accelerate both forward and reverse intersystem crossing, resulting in improved access to the triplet state. In the presence of molecular oxygen, this facilitates an increased generation of cytotoxic singlet oxygen, thereby boosting the efficacy of photodynamic therapy (PDT). These findings provide a promising supramolecular approach to advancing the application of TADF materials in aqueous-phase PDT systems.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".