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Record W4416852375 · doi:10.1111/pai.70251

Eating away at food allergy

2025· article· en· W4416852375 on OpenAlexafffund
J. Guo, Julia Upton

Bibliographic record

VenuePediatric Allergy and Immunology · 2025
Typearticle
Languageen
FieldMedicine
TopicFood Allergy and Anaphylaxis Research
Canadian institutionsHospital for Sick ChildrenUniversity of TorontoMcMaster University
FundersHospital for Sick ChildrenRegeneron PharmaceuticalsSanofi
KeywordsFood allergyIngestionSensitizationAllergyOral immunotherapyQuality of life (healthcare)Food allergensOral food challengePublic health

Abstract

fetched live from OpenAlex

Food allergy (FA) is a significant public health concern, with its prevalence rising globally and greatly affecting the lives of patients and their families. The increasing burden on healthcare systems and the impact on quality of life underscore the need for better understanding and management strategies. The dual-allergen hypothesis suggests that early skin exposure to allergens increases sensitization risk, while early oral exposure and sustained ingestion of foods promote tolerance While diet is not the only factor in FA development, eating allergenic foods early and often can profoundly prevent FA despite other risk factors such as eczema. Treatment approaches vary by a number of factors including patient preference. Avoidance remains an option, but tailored avoidance, such as allowing denatured food products with milk and egg is now commonplace. Food immunotherapy approaches via multiple routes and doses are becoming more available. Immunotherapy can result in marked reductions in food reactivity which may be sustained for weeks or months or even longer off treatment for some patients. Biologics are also being more widely offered to increase the amount of food that can be safely ingested to facilitate immunotherapy. With the current approaches, treatment at a time of low IgE formation, often associated with younger age, may be the most effective for remission, but older ages may benefit from the increase in the threshold of reactivity that food-based treatments can provide.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.588
Threshold uncertainty score0.778

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.264
Teacher spread0.252 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes2
Has abstractyes

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