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Record W4416875375 · doi:10.58931/cdt.2025.64152

An Emerging Fungal Pathogen: Trichophyton Indotineae

2025· article· W4416875375 on OpenAlexafffundabout
Benoit M. Cyrenne

Bibliographic record

VenueCanadian dermatology today. · 2025
Typearticle
Language
FieldMedicine
TopicNail Diseases and Treatments
Canadian institutionsWomen's College Hospital
FundersUniversity of TorontoWomen's College Hospital
KeywordsDermatophyteTerbinafineOutbreakEpidemiologyTrichophytonTrichophyton rubrumTrichophyton tonsurans

Abstract

fetched live from OpenAlex

Dermatophytoses are common fungal infections of the skin and other keratinized structures such as hair and nails. These infections, caused by the dermatophyte fungi, affect approximately 25% of people worldwide. Dermatophyte fungi include species from three genera: Trichophyton, Epidermophyton, and Microsporum, and may be categorized as anthropophilic, zoophilic, or geophilic. Most cases of dermatophytosis in Canada are attributable to T. rubrum. Over the past decade, there have been an increasing number of reports of terbinafine‑resistant dermatophyte infections. Most of these cases are attributable to Trichophyton indotineae, a newly described pathogen. Initially described in South and South‑East Asia, T. indotineae has quickly become a worldwide health concern, with isolates detected in more than 40 countries. Epidemiological data reviews have revealed that T. indotineae had been circulating in Oman, Iran, India, and Australia as early as 2004, with an increasing number of cases occurring after 2014 due to an outbreak in India. Recent reports suggest that most new dermatophyte infections in India are attributable to this new pathogen. The development of terbinafine resistance has been attributed to overuse of topical medications containing fixed‑dosed combinations of corticosteroids and antifungal agents, which are widely available over-the-counter in parts of Asia and Africa. This highly virulent, treatment-resistant fungus may present with chronic, extensive disease and atypical presentations, resulting in significant difficulties for both diagnosis and treatment.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.336
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0020.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.009
GPT teacher head0.289
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes3
Has abstractyes

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