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Record W4416897527 · doi:10.7759/cureus.98278

Patient Attitudes About Light Therapy and Negative Ion Therapy for Nonseasonal Depression: An Online Survey Study

2025· article· en· W4416897527 on OpenAlexaff
Orli S Hellerstein, Iman Lahouaoula, Victor W. Li, Aidan Scott, André Do, Erin E. Michalak, Jill Murphy, Samantha Huang, Raymond W. Lam

Bibliographic record

VenueCureus · 2025
Typearticle
Languageen
FieldNeuroscience
TopicCircadian rhythm and melatonin
Canadian institutionsSt. Francis Xavier UniversityUniversité de MontréalBC Children's HospitalCanadian Association of Nurses in OncologyUniversity of British Columbia
Fundersnot available
KeywordsLight therapyDepression (economics)Randomized controlled trialSurvey researchClinical trialMEDLINE

Abstract

fetched live from OpenAlex

OBJECTIVE: No studies have evaluated the feasibility of light therapy or negative ion therapy as maintenance treatments after acute antidepressant treatment in major depressive disorder. To address this gap, we surveyed people with depression about their knowledge and attitudes about light therapy and negative ion therapy, and their willingness to participate in a clinical trial of maintenance treatment with these therapies. METHODS: Participants with a self-reported diagnosis of depression completed a researcher-generated online survey, created for this study, examining awareness and effectiveness of light therapy and negative ion therapy, which included vignettes describing the use of these therapies for maintenance treatment. Participants were asked about the feasibility and reasons for wanting (and not wanting) to use the therapies instead of antidepressants. Response frequencies were compared using chi-square tests. RESULTS: A total of 193 participants completed the survey. Most were aware of both therapies, but significantly more participants had heard of light therapy (95% versus 63% for negative ion therapy, p<0.001), had used light therapy (29% versus 17%, p<0.001), and regarded light therapy as effective (54% versus 37%, p<0.001). Both therapies were considered easy to use. Most participants (81%) placed importance on finding non-medication therapies for maintenance treatment; 77% responded that they would likely volunteer for a randomized study of maintenance treatment. CONCLUSION: People with depression are aware of light therapy and negative ion therapy and support their usage as substitutes for antidepressants in maintenance treatment. This supports the importance and feasibility of a randomized relapse prevention trial with light therapy and negative ion therapy in people with depression.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.009
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.009
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.089
GPT teacher head0.349
Teacher spread0.260 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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