Abnormal gastric electrophysiology following laparoscopic sleeve gastrectomy and associations with symptoms and quality of life
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
BACKGROUND: Sleeve gastrectomy is an effective bariatric procedure but may lead to persistent symptoms without obvious mechanical cause. The normal gastric pacemaker region, which lies on the greater curvature of the corpus, is resected in sleeve gastrectomy, but the electrophysiological consequences are not adequately defined. This study assessed these impacts and associations with symptoms and quality of life (QoL) using non-invasive gastric mapping. METHODS: Patients with previous sleeve gastrectomy underwent body surface gastric mapping (Gastric Alimetry), comprising 30-minute fasting baseline and 4-hour post-prandial recordings. Analysis encompassed principal gastric frequency (PGF), body mass index-adjusted amplitude, and the Gastric Alimetry Rhythm Index (GA-RI), with comparison to reference intervals and matched controls. Symptoms were evaluated using a validated app and questionnaires. RESULTS: The study recruited 38 patients (median 36 months after surgery; range 6-119 months) and 38 controls. Of the 38 patients, 35 had at least one abnormal parameter compared with controls, typically reduced frequencies (mean(standard deviation) 2.30(0.34) versus 3.08(0.21) c.p.m., respectively; P < 0.001) and amplitudes (14.8(6.9) versus 31.5(18.0) µV, respectively; P < 0.001). Patients exhibited higher symptoms and lower QoL than the controls (Patient Assessment of Upper Gastrointestinal Disorders (PAGI) Symptoms Questionnaire scores 20 versus 7, respectively (P < 0.001); PAGI-QOL 27 versus 136, respectively (P < 0.001)). Gastric amplitude (R = 0.71, P < 0.001) and the GA-RI (R = 0.60, P = 0.02) were positively correlated with bloating, whereas amplitude was negatively correlated with heartburn (R = -0.46, P = 0.03). Lower gastric amplitudes were also correlated with greater weight loss (R = -0.45; P = 0.014). CONCLUSION: Sleeve gastrectomy modifies gastric electrophysiology due to pacemaker resection, with variable remodelling. Substantial reductions in gastric frequency and amplitude occur routinely after surgery, with specific associations between post-procedural gastric amplitude and symptoms of heartburn, bloating, and weight loss identified.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it