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Record W4416917902 · doi:10.1016/j.ahjo.2025.100690

Cardiac troponin T elevation predicts mortality in hospitalized COVID-19 patients

2025· article· en· W4416917902 on OpenAlexaff
Katelyn A. Bruno, R. Scott Wright, Joshua Culberson, Mikolaj A. Wieczorek, David O. Hodge, Patrick W. Johnson, Emily R. Whelan, Jose Malavet, Kathryn F. Larson, Jonathon W. Senefeld, Chad C. Wiggins, Stephen A. Klassen, J.F. Ricci, Taimur Sher, Rickey E. Carter, Michael J. Joyner, DeLisa Fairweather, Allan S. Jaffe

Bibliographic record

VenueAmerican Heart Journal Plus Cardiology Research and Practice · 2025
Typearticle
Languageen
FieldMedicine
TopicCOVID-19 Clinical Research Studies
Canadian institutionsBrock University
FundersNational Center for Advancing Translational SciencesNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteBiomedical Advanced Research and Development AuthorityUnitedHealth GroupU.S. Department of Health and Human ServicesOctapharmaAmerican Heart AssociationNational Institute of Allergy and Infectious DiseasesMayo Clinic
KeywordsElevation (ballistics)Troponin TTroponinClinical trialMortality rateElectrocardiography

Abstract

fetched live from OpenAlex

Objective: To evaluate if cardiac troponin values predict poor outcomes in COVID-19 patients across the range of patients of different sex and age. Methods: We examined high-sensitivity cardiac troponin T (hs-cTnT) levels in 1050 severely ill hospitalized COVID-19 patients who had hs-cTnT data available and participated in the Expanded Access Program for convalescent plasma study during the first wave (April-August 2020) of the COVID-19 pandemic. Results: We observed a continuous relationship between hs-cTnT levels and mortality in hospitalized males and females with COVID-19. This finding was present regardless of sex or age. Conclusion: These data indicate the prognostic ability of hs-cTnT to predict mortality in hospitalized COVID-19 patients across all relevant patient groups.Clinical Trials registration number: NCT04338360.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.015
metaresearch head score (Gemma)0.342
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.328
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0150.342
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.002
Science and technology studies0.0010.002
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.003
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.116
GPT teacher head0.536
Teacher spread0.420 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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