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Record W4416955094 · doi:10.1093/nar/gkaf1260

Gramene 2025: expanded comparative genomics and pathway resources, integrated search, and pan-genome portals for crop research

2025· article· en· W4416955094 on OpenAlexafffund
Andrew Olson, Sunita Kumari, Xuehong Wei, Kapeel Chougule, Zhenyuan Lu, Marcela K Tello-Ruiz, Vivek Kumar, Peter Van Buren, Catherine Kim, Janeen Braynen, Sarah Dyer, Jorge Álvarez-Jarreta, Shradha Saraf, Bruno Contreras‐Moreira, Guy Naamati, Christina Ernst, Irene Papatheodorou, Nancy George, Pankaj Jaiswal, Sushma Naithani, Parul Gupta, Justin Elser, Peter D’Eustachio, Sarah M. Assmann, Ángel Ferrero‐Serrano, Asher Pasha, Nicholas J. Provart, Nicholas Gladman, Doreen Ware

Bibliographic record

VenueNucleic Acids Research · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Mapping and Diversity in Plants and Animals
Canadian institutionsUniversity of Toronto
FundersAdvanced Research Projects AgencyWellcome TrustAgricultural Research ServiceOregon State UniversityDefense Advanced Research Projects AgencyNuclear Safety and Security CommissionCold Spring Harbor LaboratoryEuropean Molecular Biology LaboratoryNatural Sciences and Engineering Research Council of CanadaU.S. Department of AgricultureNational Aeronautics and Space AdministrationNational Institutes of HealthNational Science Foundation
KeywordsGermplasmGenomicsGenomeComparative genomicsKey (lock)Functional genomicsResource (disambiguation)Gene

Abstract

fetched live from OpenAlex

Gramene (gramene.org) is a comprehensive reference database for comparative plant genomics and pathway analysis, integrating functional annotations, evidence-based curated pathways and their projections, and multi-omics datasets. Since our last report, Gramene has added crop-specific pan-genome portals for maize, sorghum, rice, and grapevine. These pan-genome portals host population-scale datasets and multiple assembled genomes per species, all anchored by shared reference genomes. Importantly, these portals now adopt standardized rsIDs for genetic variants, advancing FAIR data principles and enabling cross-database interoperability. The main site is now Gramene Plants, emphasizing its broad genome coverage. Release 69 features 233 reference genomes, curated pathways for 139 species, expression data from 1026 studies across 27 species, and genetic variation data mapped to 27 genomes from 19 species. Key updates to the integrated search functionality include embedded expression viewers from the Bio-Analytic Resource for Plant Biology and EMBL-EBI Expression Atlas, a literature-curated catalog of gene functions, and a new Germplasm tab linking accessions with loss-of-function alleles to seed repositories. These advances reinforce Gramene as a comprehensive platform for exploring plant genomic diversity, gene function, and evolutionary conservation across the Green Tree of Life and within key agricultural species.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Software · Consensus signal: none
Teacher disagreement score0.045
Threshold uncertainty score0.151

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.005
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.002
Bibliometrics0.0060.011
Science and technology studies0.0010.000
Scholarly communication0.0030.004
Open science0.0030.005
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0450.026

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.093
GPT teacher head0.369
Teacher spread0.276 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreSoftware

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2025
Admission routes2
Has abstractyes

Explore more

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