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Record W4416960120 · doi:10.1371/journal.pone.0336688

Exploring the effect of menstrual loss and dietary habits on iron deficiency in teenagers: A cross-sectional study

2025· article· en· W4416960120 on OpenAlexaff
Lisa Söderman, Anna Stubbendorff, Linnea V. Ladfors, Beata Borgström Bolmsjö, Peter Nymberg, Moa Wolff

Bibliographic record

VenuePLoS ONE · 2025
Typearticle
Languageen
FieldMedicine
TopicMenstrual Health and Disorders
Canadian institutionsUniversity of British Columbia
FundersVetenskapsrådetKarolinska Institutet
KeywordsIron deficiencyOdds ratioMenstruationPopulationCross-sectional studyFerritinIron-deficiency anemiaMenstrual bleeding

Abstract

fetched live from OpenAlex

Adolescent girls are particularly susceptible to iron deficiency due to increased iron requirements during the pubertal growth spurt, combined with iron loss following menarche. This study aimed to investigate the prevalence of heavy menstrual bleeding in an adolescent population using the SAMANTA questionnaire and to explore its relationship with dietary habits and iron deficiency. This cross-sectional study was conducted in two Swedish high schools in 2023. Post-menarchal female students, aged 15 and older, were included (n = 394). Data were collected on-site through a patient-reported survey, including the SAMANTA questionnaire for heavy menstrual bleeding, and by blood sampling. Meat-restricted diet was analyzed in relation to iron status. Descriptive analysis and regression analysis were used to assess the prevalence of heavy menstrual bleeding and its relationship with dietary habits and iron deficiency, defined as ferritin <15 µg/L. The prevalence of heavy menstrual bleeding and iron deficiency in the cohort was 53% (208/394) and 40% (157/394), respectively. In univariate analysis, heavy menstrual bleeding (OR 3.0, 95% CI [2.0, 4.6]) and a meat-restricted diet (OR 3.5, 95% CI [2.2, 5.6]) were both associated with increased odds of iron deficiency. When assessing the joint effect of having heavy menstrual bleeding and a meat-restricted diet, the odds of iron deficiency were 13.5 times higher compared to omnivore individuals with normal menstruation (OR 13.5, 95% CI [6.4, 28.7]). Overall, the prevalence of iron deficiency in this population of adolescent girls was very high. Heavy menstrual bleeding and a meat-restricted diet were both independently associated with increased odds of iron deficiency. However, odds for iron deficiency were monumentally higher when combining these two variables, thus highlighting the importance of assessing and addressing both excessive output and low intake of iron.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.279

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.104
GPT teacher head0.333
Teacher spread0.229 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations3
Published2025
Admission routes1
Has abstractyes

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