3D Conditional Image Synthesis of Left Atrial LGE MRI from Composite Semantic Masks
Bibliographic record
Abstract
Segmentation of the left atrial (LA) wall and endocardium from late gadolinium-enhanced (LGE) MRI is essential for quantifying atrial fibrosis in patients with atrial fibrillation. The development of accurate machine learning-based segmentation models remains challenging due to the limited availability of data and the complexity of anatomical structures. In this work, we investigate 3D conditional generative models as potential solution for augmenting scarce LGE training data and improving LA segmentation performance. We develop a pipeline to synthesize high-fidelity 3D LGE MRI volumes from composite semantic label maps combining anatomical expert annotations with unsupervised tissue clusters, using three 3D conditional generators (Pix2Pix GAN, SPADE-GAN, and SPADE-LDM). The synthetic images are evaluated for realism and their impact on downstream LA segmentation. SPADE-LDM generates the most realistic and structurally accurate images, achieving an FID of 4.063 and surpassing GAN models, which have FIDs of 40.821 and 7.652 for Pix2Pix and SPADE-GAN, respectively. When augmented with synthetic LGE images, the Dice score for LA cavity segmentation with a 3D U-Net model improved from 0.908 to 0.936, showing a statistically significant improvement ($p\lt 0.05$) over the baseline. These findings demonstrate the potential of label-conditioned 3D synthesis to enhance the segmentation of under-represented cardiac structures.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".