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Record W4417106817 · doi:10.1038/s41598-025-29316-4

Contrasting pre-vaccine COVID-19 waves in Italy through functional data analysis

2025· article· en· W4417106817 on OpenAlexafffund
Tobia Boschi, Jacopo Di Iorio, Lorenzo Testa, Marzia A. Cremona, Francesca Chiaromonte

Bibliographic record

VenueScientific Reports · 2025
Typearticle
Languageen
FieldMathematics
TopicCOVID-19 epidemiological studies
Canadian institutionsUniversité Laval
FundersFonds de Recherche du Québec - SantéNatural Sciences and Engineering Research Council of CanadaHuck Institutes of the Life Sciences
KeywordsFunctional data analysisRegression analysisGovernment (linguistics)Differential (mechanical device)SmoothingQuality (philosophy)

Abstract

fetched live from OpenAlex

This study analyzes mortality patterns during two pre-vaccine COVID-19 waves in Italy, using data from its 107 provinces. Mortality is examined alongside information on mobility, governmental restrictions, and socio-demographic, infrastructural, and environmental factors using Functional Data Analysis tools. Publicly available differential mortality data and local mobility data from Google are processed with smoothing splines and aligned through landmark registration. The resulting curves are clustered to identify mortality patterns, and regression models are used to evaluate the impact of mobility, restrictions, and other factors on mortality. We find significant differences between the two waves: the first had higher, more concentrated mortality peaks, while the second was more widespread and asynchronous. Our results also support the effectiveness of timely restrictions in curbing mortality, and a strong positive association between local mobility and mortality in both pre-vaccine waves. Despite data quality limitations, our findings strengthen the evidence for the role of government restrictions and mobility controls during the pandemic.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.010
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.068
Threshold uncertainty score0.135

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.010
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.001
Bibliometrics0.0030.004
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0010.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.297
GPT teacher head0.460
Teacher spread0.163 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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