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20 Racial Disparities in Surgical Rates Among Hospitalized Patients With Inflammatory Bowel Disease: A Meta-Analysis

2025· article· en· W4417175952 on OpenAlexaboutno aff
YOUSSEF S. HAFEZ, Ahmed Elmasry, Howaida El‐Said, Abdulrahman S. El-Rayik, Mohamed S. Ibrahim, May Abdel–Wahab, Clive J. Miranda

Bibliographic record

VenueThe American Journal of Gastroenterology · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsnot available
Fundersnot available
KeywordsInflammatory Bowel DiseasesInflammatory bowel diseaseMEDLINESurgical procedures

Abstract

fetched live from OpenAlex

Background: Surgical intervention is a critical component of care for hospitalized patients with inflammatory bowel disease (IBD). Whether surgical utilization is influenced by race remains unclear, with the overall impact yet to be clearly defined due to inconsistent evidence in the literature. Methods: This meta-analysis, following PRISMA guidelines, assessed racial disparities in surgical interventions among hospitalized IBD patients. A systematic search of PubMed, Google Scholar, and Scopus (2020–2025) identified cohort, case-control, and cross-sectional studies. After screening 1,155 records, 4 studies were included. Random-effects models compared surgical intervention rates between Black, Asian, Hispanic, and White patients. Study quality was evaluated using the Newcastle-Ottawa Scale, and heterogeneity was assessed using I2 and Chi2 statistics. Publication bias was examined with funnel plots (P < 0.05), and effect sizes were estimated using the generic inverse variance method. Results: A total of 4 observational studies (n = 566,209 participants) were included, comprising 32,026 Black, 8,868 Asian, 27,327 Hispanic, and 271,452 White patients. The pooled analysis using a random-effects model showed no statistically significant difference in surgical rates between Black and White patients (pooled OR: 0.81, 95% CI [0.54–1.21], P = 0.30), with substantial heterogeneity (I2 = 98%, Chi-square P = 101.65). Subgroup analysis revealed a statistically significant increase for Black patients (pooled OR: 0.70, 95% CI [0.48–1.03], P = 0.03), with reduced heterogeneity (I2 = 72.1%, Chi-square P = 7.17), and point estimates trended toward a higher surgical rate among Black patients. For Hispanic versus non-Hispanic White patients, no significant overall difference was observed (pooled OR: 0.7, 95% CI [0.53–1.06], P = 0.11), with high heterogeneity (I2 = 96%, Chi-square P = 53.43). Sensitivity analysis excluding (Shustak 2024) showed a modest but significant increase for Hispanic patients (pooled OR: 0.65, 95% CI [0.51–0.83], P = 0.003), with reduced heterogeneity (I2 = 89%, Chi-square P = 9.11). Asian patients showed no significant difference versus White patients (pooled OR: 0.78, 95% CI [0.57–1.06], P = 0.11), with high heterogeneity (I2 = 93%, Chi-square P = 13.96). Subgroup analysis showed a significant increase in surgical rate (pooled OR: 0.75, 95% CI [0.61–0.92], P = 0.01), with reduced heterogeneity (I2 = 56.2%, Chi-square P = 4.57), and point estimates also trended higher surgical rate among Asian patients. Conclusions: This meta-analysis suggests that racial minorities with IBD may experience slightly higher surgical utilization compared to White patients, particularly among Black, Hispanic, and Asian populations in subgroup and sensitivity analyses. These findings likely reflect underlying healthcare disparities, including delayed diagnosis, limited access to medical therapy, and challenges with follow-up and health literacy. While heterogeneity across studies and a small sample size limit definitive conclusions, the consistent trend highlights the need for interventions to improve equitable access to timely diagnosis and medical therapy. Future prospective studies should further explore these disparities to better inform strategies that reduce surgical burden in minority populations.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.018
metaresearch head score (Gemma)0.033
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: Meta-analysis
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.018
Threshold uncertainty score0.097

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0180.033
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0140.087
Bibliometrics0.0070.005
Science and technology studies0.0010.001
Scholarly communication0.0040.001
Open science0.0020.002
Research integrity0.0030.002
Insufficient payload (model declined to judge)0.0050.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.233
Teacher spread0.229 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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