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Record W4417179080 · doi:10.18192/uojm.v15i2.7450

Xenotransplantation Unveiled: Breakthroughs, Challenges, and Public Perceptions

2025· article· en· W4417179080 on OpenAlexaffvenue
James V. Vowles

Bibliographic record

VenueUniversity of Ottawa Journal of Medicine · 2025
Typearticle
Languageen
FieldMedicine
TopicXenotransplantation and immune response
Canadian institutionsUniversity of Ottawa
Fundersnot available
KeywordsXenotransplantationEthical issuesTransplantation

Abstract

fetched live from OpenAlex

Xenotransplantation has recently made headlines in recent media reports showcasing the advancement and potential of this process. However, with this recognition comes questions, doubts, and disbelief. The primary aim of this paper is to traverse and unravel what xenotransplantation is, discuss recent breakthroughs, benefits and challenges as well as consider societal perceptions. Ultimately, this discussion will bridge the gap in knowledge with respect to the current public understanding of the state of xenotransplantation and its future healthcare implications. ---------- La xénotransplantation a récemment fait la une des médias, qui ont mis en avant les progrès et le potentiel de ce procédé. Cependant, cette reconnaissance s’accompagne de questions, de doutes et d’incrédulité. Ce commentaire passe en revue les récentes avancées scientifiques, notamment les modifications génétiques rendues possibles par la technologie CRISPR et le développement d’organes chimériques humains-porcins, tout en abordant les obstacles immunologiques, les préoccupations éthiques et la perception du public. Bien que des défis majeurs subsistent, tels que le rejet immunitaire et l’acceptation sociale, la xénotransplantation offre une stratégie prometteuse pour remédier à la pénurie critique d’organes et transformer les soins de santé à l’avenir.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.020
metaresearch head score (Gemma)0.022
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.020
Threshold uncertainty score0.105

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0200.022
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0060.013
Scholarly communication0.0140.014
Open science0.0010.005
Research integrity0.0060.012
Insufficient payload (model declined to judge)0.0050.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.258
Teacher spread0.238 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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Same venueUniversity of Ottawa Journal of MedicineSame topicXenotransplantation and immune responseFrench-language works237,207