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Record W4417197880 · doi:10.2147/jpr.s553033

A Primer on Anatomy, Biophysics, Pathology, Imaging and Treatment of the Intervertebral Disc and the Anterior Spinal Column: The Discogenic, Intervertebral, Spinal Column (DISC) ASPN Workgroup

2025· article· en· W4417197880 on OpenAlexaff
Jay S. Grider, Timothy R. Deer, Douglas P. Beall, Melissa Murphy, J. W. Fleming, Steven Falowski, Christopher Mallard, Hamzah Adel Ramawad, Rosa Garcia, Usman Latif, Chau Vu, Anne Christopher, Michael Harned, Raj G Patel, Anuj Shah, I. Cowan, Kristin Jarzombek, Nasir Khatri, Mateusz Graca, Marcin Karcz, Timothy T. Davis, Kaku Barkoh, Olivier Clerk-Lamalice, Brian Durkin, Mark N. Malinowski, Dagmar K. Gross, Thomas P. Hedman, Matthew Green, Michael J. Dorsi, Kasra Amirdelfan, Dawood Sayed

Bibliographic record

VenueJournal of Pain Research · 2025
Typearticle
Languageen
FieldMedicine
TopicSpine and Intervertebral Disc Pathology
Canadian institutionsMedtronic (Canada)University of Calgary
Fundersnot available
KeywordsSpinal columnWorkgroupVertebral columnPrimer (cosmetics)Intervertebral discDegenerative disc diseasePathological

Abstract

fetched live from OpenAlex

Objective: As therapeutic options are rapidly expanding to treat pain of discogenic and vertebrogenic origin, it is important for the clinician to have an evidence-based understanding of the latest information regarding the normal and pathological anatomy of the intervertebral disc as well as imaging characteristics and treatment strategies. The American Society of Pain and Neuroscience (ASPN) commissioned the DISC project to inform and update the interventional spine community about anterior column pain syndromes. Methods: Using established literature review methods a clinical oversight group was convened to create an outline covering topics that will be key to meeting the objectives delineated by the ASPN scientific and guidelines leadership. This oversight group, using the created outline, selected key opinion leaders and experts to assemble the latest information on anterior column and intervertebral disc anatomy and treatment to serve as a living document that can be continuously updated to drive best practices and innovation. Results: A review of normal and pathological anatomy, a comprehensive understanding of biophysics applied to the anterior spinal column, and understanding of the current state of practice with regard to imaging, diagnostic classification systems and treatment.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.631
Threshold uncertainty score0.982

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0040.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.000
Science and technology studies0.0000.003
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.037
GPT teacher head0.393
Teacher spread0.355 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes1
Has abstractyes

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