Abstract C005: APC Mutation-induced Retardation of Tissue Renewal is Fundamental to Colon Tumorigenesis
Bibliographic record
Abstract
Abstract Every tissue-type has a specific rate of renewal that maintains its structural integrity throughout life. Our Aim is to understand how changes in the rate of tissue renewal underlie colon cancer development. For colon tumorigenesis, we measured kinetic changes that occur in human and murine intestinal crypts having different APC genotypes. Quantitative histologic mapping showed that transitions between the different cell phenotypes are progressively delayed along the axis of APC mutant crypts. The extent of this delay was greater in homozygous than in heterozygous APC-mutant crypts. In ApcMin/+ mouse intestine, clearance of BrdU from pre-labeled crypts was significantly slower than in wildtype-Apc mice. Kinetic modeling showed that retarded crypt renewal increases the number of cell divisions required for differentiation which causes incomplete differentiation and progressive expansion of the proliferative cell populations. Thus, our findings reveal that APC mutation-induced retardation of tissue renewal is a key driver mechanism in colon tumor initiation and development. Citation Format: Bruce Boman. APC Mutation-induced Retardation of Tissue Renewal is Fundamental to Colon Tumorigenesis [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: The Rise in Early-Onset Cancers—Knowledge Gaps and Research Opportunities; 2025 Dec 10-13; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(23_Suppl):Abstract nr C005.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.012 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".