The role of epicardial fat in the progression of cardiovascular disease in women
Bibliographic record
Abstract
Obesity is a global health burden with significant sex-specific implications, especially in cardiovascular disease (CVD). Epicardial fat tissue (EFT), a metabolically active visceral fat depot between the myocardium and visceral pericardium, plays a critical role in cardiac health. Under normal conditions, EFT supports the heart via anti-inflammatory signaling, fatty acid metabolism, and nitric oxide–mediated vasodilation. However, in obesity and cardiometabolic syndrome, EFT becomes proinflammatory, contributing to cardiac remodeling and endothelial dysfunction. Since women experience unique hormonal and metabolic influences, risk factors such as menopause, polycystic ovarian syndrome, vitamin D deficiency, and sleep apnea are linked to increased EFT in women, independent of body mass index, and correlate with adverse cardiac remodeling and inflammation. Therapeutic strategies such as exercise, GLP-1 receptor agonists, and hormone replacement therapy show promise in reducing EFT. Understanding sex-specific EFT biology is essential for personalized CVD prevention and treatment in obesity-related disorders.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".