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Hydrogels with multiple characteristic pore dimensions: From transport properties to multifunctional materials

2025· article· en· W4417214353 on OpenAlexafffund
Yuhang Huang, Eugenia Kumacheva

Bibliographic record

VenueProgress in Polymer Science · 2025
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicHydrogels: synthesis, properties, applications
Canadian institutionsUniversity of Toronto
FundersNatural Sciences and Engineering Research Council of Canada
KeywordsSelf-healing hydrogelsPolymerPorositySwelling

Abstract

fetched live from OpenAlex

Hydrogels with multiple characteristic pore dimensions (HMPs) have emerged as a powerful class of soft materials inspired by biological systems. By incorporating distinct average pore sizes into a single network, simultaneous control over competing hydrogel transport properties can be achieved, including throughput and selectivity, both of which are important in drug delivery, tissue engineering, catalysis, sensing, and water remediation hydrogel applications. This review highlights recent advances in the design, synthesis, characterization, and applications of HMPs. It highlights the fundamental principles of transport in these hydrogels, including the role of spatial arrangement of regions with different pore dimensions in probe mobility and fluid flow. Experimental and theoretical characterization of distinct pore dimensions in HMPs is followed by the discussion of the contribution of multiple pore dimensions to HMP functionality. The review provides the summary of the strategies for fabricating HMPs and their applications. An outlook highlights key challenges and future opportunities in this field to advance HMPs as the new generation of hydrogel-based materials for diverse applications.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.001
Threshold uncertainty score0.003

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.001
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.247
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations5
Published2025
Admission routes2
Has abstractyes

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