Antitumor Activity of Death Receptor 5-Targeted Camptothecin-Loaded Nanoparticles in Murine Syngeneic Models
Bibliographic record
Abstract
High Resolution Image Download MS PowerPoint Slide Death receptor 5 (DR5) is a key mediator of the extrinsic apoptotic pathway that is often upregulated in tumors, rendering it an attractive target for cancer therapy. Activation of DR5 requires oligomerization, which can be achieved through multivalent presentation of DR5 ligands on nanoparticles. DR5-targeted nanoparticles can efficiently agonize DR5 to inhibit the growth of human xenografts, although it remains unclear whether these effects would translate to a syngeneic tumor model with an immunocompetent microenvironment. Here, we develop camptothecin-loaded polymeric nanoparticles coated with the murine DR5 antibody MD5–1 and demonstrate their pro-apoptotic effects in murine cell lines in vitro . Moreover, we show that these nanoparticles inhibit the growth of MC38 colorectal allografts in vivo by >90% relative to control nanoparticles. Collectively, our work confirms that the antitumor efficacy of DR5-targeted nanoparticles extends to syngeneic models, paving the way for future studies to explore their impact on tumor immunity and the surrounding microenvironment.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".