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Record W4417221675 · doi:10.1093/nc/niaf049

Reimagining pain as an allostatic imperative: perspectives from contemplative traditions

2025· article· en· W4417221675 on OpenAlexaff
Catherine Prueitt, Idil Sezer, Matthew D. Sacchet

Bibliographic record

VenueNeuroscience of Consciousness · 2025
Typearticle
Languageen
FieldPsychology
TopicMindfulness and Compassion Interventions
Canadian institutionsUniversity of British Columbia
Fundersnot available
KeywordsAllostasisAllostatic loadContemplationConstructiveAdaptation (eye)OrganismAffect (linguistics)Mindfulness

Abstract

fetched live from OpenAlex

The motivational force of pain is undeniable. But what pain commands us to do, how we might satisfy this command, and if our experience of pain is inherently linked to suffering are far murkier topics. This paper brings together empirical studies of pain reprocessing during advanced meditation, the rise of allostatic paradigms to account for biological self-regulation, and the philosophy of pain in the classical Sanskrit philosophical tradition of Pratyabhijñā Śaivism to argue that pain is an allostatic imperative to adapt a part of one's body. We theorize two components of an allostatic response, heterostatic and homeostatic, that work in tandem to address pain as an allostatic command. Homeostatic responses are error-corrective in that they seek to protect an organism by returning to a previously stable steady state. Heterostatic responses are anticipatory in that they seek to better prepare an organism to meet future challenges by proactively shifting to a new steady state. We note that an organism's successful adaptation to its environment depends not just on error-correction, but also on anticipatory change. We theorize that a broad range of affect properly accompanies pain. We propose potential directions for empirically developing this model. We also note the possibility that this model could be extended to account for mental pain.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.005
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.005
Threshold uncertainty score0.025

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0050.004
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0030.047
Scholarly communication0.0050.007
Open science0.0010.004
Research integrity0.0030.007
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.369
Teacher spread0.337 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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