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Record W4417244577 · doi:10.1016/j.ccell.2025.11.006

Multi-omic landscape of human gliomas from diagnosis to treatment and recurrence

2025· article· en· W4417244577 on OpenAlexfundno aff
Hadeesha Piyadasa, Benjamin Oberlton, Mikaela Ribi, Ke Xuan Leow, Jolene S. Ranek, Inna Averbukh, Meelad Amouzgar, Candace C. Liu, Davide Franchina, Noah F. Greenwald, Erin McCaffrey, Rashmi Kumar, Selena Ferrian, Albert G. Tsai, Ferda Filiz, Christine Camacho Fullaway, Marc Bossé, Sricharan Reddy Varra, Alex Kong, C. H. Sowers, Melanie Hayden Gephart, Pablo Nuñez-Perez, Enjun Yang, Mike Travers, Samantha Liang, Mariarita Santi, Samantha Bucktrout, Pier Federico Gherardini, John E. Connolly, Kristina A. Cole, Michael E. Barish, Christine E. Brown, Derek A. Oldridge, Joanna J. Phillips, Hideho Okada, Robert M. Prins, Sean C. Bendall, Michael Angelo

Bibliographic record

VenueCancer Cell · 2025
Typearticle
Languageen
FieldMedicine
TopicGlioma Diagnosis and Treatment
Canadian institutionsnot available
FundersNational Institute of Neurological Disorders and StrokeUniversity of California, San FranciscoParker Institute for Cancer ImmunotherapyNational Heart, Lung, and Blood InstituteCenter for Strategic Scientific Initiatives, National Cancer InstituteStanford Graduate School of EducationV Foundation for Cancer ResearchNational Cancer InstituteNational Institutes of HealthCanadian Institutes of Health ResearchAlliance for Cancer Gene Therapy
KeywordsIsocitrate dehydrogenaseGliomaMyeloid cellsTumor microenvironmentGlioblastomaImmune systemImmunotherapyIDH1Transcriptome

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.494
Threshold uncertainty score0.609

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.322
Teacher spread0.295 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations17
Published2025
Admission routes1
Has abstractno

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