FtsZ contributes to cytoadhesion and interaction with host extracellular matrix components and plasminogen in Mycoplasma bovis
Bibliographic record
Abstract
Mycoplasma bovis causes serious diseases in cattle and is one of the most economically important pathogens threatening the global cattle industry. It is still a great challenge to prevent and control M. bovis infections owing to the increase in antibiotics resistance and unsatisfactorily effective commercial vaccines. FtsZ is commonly considered as a division protein in most bacteria. Owing to the limited genetic manipulation tools of M. bovis, the role of FtsZ in the pathogenicity of M. bovis remains unknown. In this study, FtsZ protein was found to be mainly distributed on the cell membrane, was highly conserved, and had good immunogenicity. FtsZ could bind to embryonic bovine lung cells (EBL) membrane extract, and this binding was inhibited by anti-FtsZ serum. In addition, FtsZ interacted with host extracellular matrix components fibronectin, laminin, vitronectin, and collagen IV in a dose-dependent manner, and promoted tissue diffusion by activating plasminogen through tissue plasminogen activator (tPA). Disruption of the ftsZ gene markedly reduced the adhesion of M. bovis to EBL cells while the complemented strain M. bovis ΔftsZ: ftsZ partly restored the adhesion ability. This is a first description that FtsZ acts as a novel adhesion protein in Mycoplasma, which interacts with host extracellular matrix components and plasminogen, and plays a vital role in adhesion and dissemination. This study expands our understanding of FtsZ significant role in the pathogenicity of M. bovis and provides a new potential vaccine and drug target against M. bovis infections.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".