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Impacts of COVID-19 on pediatric patients with congenital heart disease: a small systematic and integrative literature review

2025· review· en· W4417278508 on OpenAlexaboutno aff
Alexandre D’Annibale Cartøgenes, Luigi Chermont Berni, Laíse Maria Barbosa Amaral, Rafael Machado, Rita de Cássia Silva de Oliveira

Bibliographic record

VenueRevista Paulista de Pediatria · 2025
Typereview
Languageen
FieldMedicine
TopicCOVID-19 Clinical Research Studies
Canadian institutionsnot available
Fundersnot available
KeywordsHeart diseasePandemicMEDLINEPrimary careChild health

Abstract

fetched live from OpenAlex

OBJECTIVE: The objective of this study was to compile primary studies to understand the impacts of COVID-19 on pediatric patients with congenital heart disease. DATA SOURCE: A systematic review based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) method, with searches conducted in the PubMed, Latin American and Caribbean Health Sciences Literature (LILACS), and Scientific Electronic Library Online (SciELO) databases. Studies published in the last 5 years, open access, and addressing the research question, "What are the main impacts of COVID-19 on pediatric patients with congenital heart disease?" were included. The risk of bias was assessed using the Newcastle-Ottawa Scale (NOS) and the Joanna Briggs Institute (JBI) tools. DATA SYNTHESIS: A total of 377 articles were identified, of which 12 met the inclusion criteria. The NOS tool indicated that two of the eight cohort studies had a risk of bias and lower methodological quality. The JBI tool revealed that three of the four cross-sectional studies had a low risk of bias and good methodological quality. The integrative analysis highlighted three main impacts of COVID-19 on these patients: difficulties in follow-up and treatment, reduced physical activity due to social distancing, and postponement of procedures and surgeries. Infected patients experienced increased complications and hospitalizations, but without a significant change in mortality. CONCLUSIONS: The COVID-19 pandemic significantly affected the health and management of congenital heart disease, leading to clinical complications and worsening follow-up. Further primary and secondary studies are needed to strengthen the evidence and improve patient management.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.181
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch, Meta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Systematic review · Consensus signal: Systematic review
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.251
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0020.181
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0070.001
Bibliometrics0.0010.002
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.034
GPT teacher head0.407
Teacher spread0.373 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designSystematic review
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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