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Record W4417296748 · doi:10.1093/pch/pxaf116.108

108 Three-year mortality and disability in very preterm and low birthweight infants cared for in single family rooms versus open bay units: Randomized Controlled Trial

2025· article· en· W4417296748 on OpenAlexaffabout
Michael J. Vincer, Christy Woolcott, Darlene Inglis, Tanya M Myles, Susan M. MacDonald, Jehier Afifi, David C. Simpson, Satvinder Ghotra, Walid El‐Naggar, Balpreet Singh, Danielle M Styranko, Sharon Unger, Souvik Mitra, Douglas McMillan, Jon Dorling

Bibliographic record

VenuePaediatrics & Child Health · 2025
Typearticle
Languageen
FieldMedicine
TopicInfant Development and Preterm Care
Canadian institutionsUniversity of British ColumbiaIzaak Walton Killam Health CentreDalhousie University
Fundersnot available
KeywordsRandomized controlled trialGestational ageInfant mortalityNeonatal intensive care unitBlindnessNeonatal mortalityIntensive care

Abstract

fetched live from OpenAlex

Abstract Background Single family room (SFR) neonatal intensive care units (NICU) may be better than the open bay (OB) NICU although mortality is similar and language scores are lower in very preterm (VP) infants cared for in SFR. Objectives To compare the composite outcome of death or disability by 36 months corrected gestational (CGA) in VP or very low birthweight (VLBW) infants treated in a SFR versus an OB. Design/Methods Reconstruction of the NICU at the Izaak Walton Killam Hospital, Halifax, Nova Scotia resulted in a 440-day period when both a SFR and an OB co-existed. All NICU admissions were randomized to either the SFR or OB but only VP (< 31 weeks) and VLBW (<= 1500 grams) infants were eligible for the outcome measures. The primary outcome was death or disability (cerebral palsy, language or cognitive delay, blindness or deafness) at 36 months CGA. Each component of the primary outcome was a secondary outcome. Results 819 randomly allocated infants were admitted to NICU of which 85 were enrolled in the trial, 43 to SFR and 42 to OB. Initial state variables were similar (Table 1). The primary outcome was similar between groups (Fisher exact p-value = 0.650); however, mortality was lower in SFR than OB (Fisher exact p-value = 0.029) as noted in Table 2. Conclusion The primary outcome of death or disability was similar between the two groups; however, there was a significant reduction in mortality in VP or VLBW infants cared for in the SFR NICU compared to the OB NICU.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.027

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0030.004
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0060.004
Bibliometrics0.0010.001
Science and technology studies0.0010.002
Scholarly communication0.0020.001
Open science0.0020.001
Research integrity0.0040.003
Insufficient payload (model declined to judge)0.0080.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.029
GPT teacher head0.314
Teacher spread0.285 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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