Placental Chronic Histiocytic Intervillositis: Pregnancy Outcomes and Complications, a Systematic Review and Meta-Analysis
Bibliographic record
Abstract
Chronic histiocytic intervillositis (CHI) is a rare placental inflammatory condition characterized by the infiltration of monocytes into the intervillous space. CHI is associated with serious neonatal complications. In the present systematic review and meta-analysis, we assessed the relationship between CHI and maternal and neonatal outcomes. The meta-analysis involved searching databases such as EMBASE, PubMed, Web of Science, and SCOPUS for studies on idiopathic CHI up to May 1, 2024. Included studies assessed pregnancy outcomes, including gestational age and live birth status, while excluding nonidiopathic cases. The quality of the studies and risk of bias were evaluated using the Newcastle-Ottawa Quality Scale (NOS). Meta-analyses were then conducted to estimate the frequencies of various pregnancy outcomes. Initially, 402 articles were identified, leading to the inclusion of 12 studies that met the criteria for final analysis. The studies encompassed a total of 568 pregnancies, with sample sizes ranging from 16 to 111 participants and mean ages between 29.8 and 34 yr. The meta-analysis revealed pooled frequencies of 40% for intrauterine growth retardation (IUGR), 55% for live births, and 20% for intrauterine fetal death (IUFD). Sensitivity analyses demonstrated no significant differences when the analysis was restricted to low-risk studies. In conclusion, this meta-analysis highlights the significant associations between CHI and adverse pregnancy outcomes, including high rates of intrauterine growth retardation and intrauterine fetal death. These findings underscore the importance of early detection and management of CHI.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.007 | 0.002 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".