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Record W4417427848 · doi:10.1177/09622802251403355

Joint mixed-effects models for causal inference in clustered network-based observational studies

2025· article· en· W4417427848 on OpenAlexafffund
Vanessa McNealis, Erica E. M. Moodie, Nema Dean

Bibliographic record

VenueStatistical Methods in Medical Research · 2025
Typearticle
Languageen
FieldMathematics
TopicAdvanced Causal Inference Techniques
Canadian institutionsMcGill University
FundersFonds de recherche du Québec – Nature et technologiesFonds de Recherche du Québec - SantéUniversity of North Carolina at Chapel HillNational Institute of Child Health and Human DevelopmentAlliance de recherche numérique du CanadaNatural Sciences and Engineering Research Council of CanadaEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentCanada Research ChairsMcGill University
KeywordsCausal inferenceInferenceObservational studyContext (archaeology)Outcome (game theory)Bayesian inferenceCausal modelBayesian probabilityLatent variable

Abstract

fetched live from OpenAlex

Causal inference on populations embedded in social networks poses technical challenges, since the typical no-interference assumption frequently does not hold. Existing methods developed in the context of network interference rely upon the assumption of no unmeasured confounding. However, when faced with multilevel network data, there may be a latent factor influencing both the exposure and the outcome at the cluster level. We propose a Bayesian inference approach that combines a joint mixed-effects model for the outcome and the exposure with direct standardisation to identify and estimate causal effects in the presence of network interference and unmeasured cluster confounding. In simulations, we compare our proposed method with linear mixed and fixed effects models and show that unbiased estimation is achieved using the joint model. Having derived valid tools for estimation, we examine the effect of home environment on adolescent school performance using data from the National Longitudinal Study of Adolescent Health.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.025
metaresearch head score (Gemma)0.390
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMetaresearch
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: Theoretical or conceptual
GenreCandidate signal: Methods · Consensus signal: Methods
Teacher disagreement score0.366
Threshold uncertainty score0.903

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0250.390
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.002
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.759
GPT teacher head0.705
Teacher spread0.054 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designTheoretical or conceptual
Domainnot available
GenreMethods

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

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