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Record W4417457695 · doi:10.1017/s2040174425100275

Early life trajectories of head circumference predict executive function and fluid cognitive skills at age 4 in Kenya

2025· article· en· W4417457695 on OpenAlexfundno aff
Michael T. Willoughby, Hemstone Mugala, Rachel Kamau, Brent R. Collett, Emily R. Begnel, Ednah Ojee, Judith Adhiambo, Eliza Mabele, Soren Gantt, Sarah Benki‐Nugent, Cheryl L. Day, Jennifer Slyker, John Kinuthia, Dalton Wamalwa

Bibliographic record

VenueJournal of Developmental Origins of Health and Disease · 2025
Typearticle
Languageen
FieldMedicine
TopicInfant Development and Preterm Care
Canadian institutionsnot available
FundersEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentCanadian Institutes of Health ResearchNational Institute of Child Health and Human DevelopmentNational Institute of Allergy and Infectious DiseasesCenter for AIDS Research, University of WashingtonUniversity of Washington
KeywordsNeurocognitiveCognitionCohortLatent growth modelingHead circumferenceNormativeCognitive skillCognitive development

Abstract

fetched live from OpenAlex

Abstract Head circumference (HC) is a low-cost proxy for early brain development, yet few studies have examined its predictive value for specific neurocognitive outcomes in low- and middle-income countries. This study investigated whether trajectories of HC growth from 1 to 24 months predict executive function and fluid cognitive skills at age 4 in a Kenyan cohort ( N = 182). Using latent growth curve modeling, we found that greater HC growth was significantly associated with better EF and fluid cognitive skills, independent of initial HC and sociodemographic factors. These associations were robust across subgroups defined by prenatal exposure to HIV and atypical physical growth (i.e., extreme values for weight-for-length, underweight, or HC). Moreover, the predictive association between early HC and later neurocognition was evident within the first 15 months of life. This study highlights the value of monitoring changes in HC as one aspect of early child health and wellbeing. Infants who do not exhibit normative increases in HC in infancy may benefit from early neurocognitive assessments and/or the receipt of early intervention services.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.082
Threshold uncertainty score0.163

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.284
Teacher spread0.270 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations0
Published2025
Admission routes1
Has abstractyes

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