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Record W4417502331 · doi:10.1038/s41467-025-67470-5

Connecting algorithmic fairness and fair outcomes in a sociotechnical simulation case study of AI-assisted healthcare

2025· article· en· W4417502331 on OpenAlexafffund
Emma A. M. Stanley, Roger Y. Tsang, Haley Gillett, Raissa Souza, Vibujithan Vigneshwaran, Chris Kang, Melissa D. McCradden, Matthias Wilms, Nils D. Forkert

Bibliographic record

VenueNature Communications · 2025
Typearticle
Languageen
FieldMedicine
TopicArtificial Intelligence in Healthcare and Education
Canadian institutionsHotchkiss Brain InstituteSickKids FoundationAlberta Children's HospitalAlberta Cancer FoundationUniversity of Calgary
FundersNatural Sciences and Engineering Research Council of CanadaCanadian Institutes of Health ResearchAlberta InnovatesKillam TrustsCanada Research ChairsGovernment of Canada
KeywordsSociotechnical systemHealth careFairness measureHealthcare systemHealth equityAffect (linguistics)

Abstract

fetched live from OpenAlex

Artificial intelligence (AI) has vast potential for improving healthcare delivery, but concerns regarding biases in these systems have raised important questions regarding fairness when deployed clinically. Most prior studies on fairness in clinical AI focus solely on performance disparities between subpopulations, which often fall short of connecting the technical outputs of AI systems with sociotechnical outcomes. In this work, we present a simulation-based approach to explore how statistical definitions of algorithmic fairness translate to fairness in long-term outcomes, using AI-assisted breast cancer screening as a case example. We evaluate four fairness criteria and their impact on mortality rates and socioeconomic disparities, while also considering how clinical decision makers’ reliance on AI and patients’ access to healthcare affect outcomes. Our results highlight how algorithmic fairness does not directly translate into fair and equitable outcomes, underscoring the importance of integrating sociotechnical perspectives to gain a holistic understanding of fairness in healthcare AI. Artificial intelligence (AI) can greatly improve healthcare delivery and outcomes, but potential embedded biases can affect fairness in clinical deployment. Here, the authors develop a simulation-based approach to explore which formalisations of AI algorithmic fairness translate into long-term outcome fairness, with a focus on breast cancer.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.018
metaresearch head score (Gemma)0.063
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesScience and technology studies
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.997
Threshold uncertainty score0.093

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0180.063
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0030.005
Scholarly communication0.0040.003
Open science0.0020.004
Research integrity0.0030.003
Insufficient payload (model declined to judge)0.0060.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.163
GPT teacher head0.530
Teacher spread0.367 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designSimulation or modeling
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes2
Has abstractyes

Explore more

Same venueNature Communications→Same topicArtificial Intelligence in Healthcare and Education→French-language works237,207→