C57BL/6 Mouse Substrain Differences in the Ontogeny of Auditory Fear
Bibliographic record
Abstract
Early life adversity is a major risk factor for mental disorders later in life. Genetic and individual differences modulate the impact of early life trauma and stress on adult mental health, emphasizing the importance of understanding how the early onset of individual differences may shape behavioral outcomes across life. In rodents, genetic differences can be studied using inbred rodent strains or substrains. While C57BL/6 mouse substrains differ in their adult fear behavior, it is unclear when in development these differences emerge. Here we compared the ontogenesis of remote auditory fear retrieval, spontaneous recovery and renewal in the mouse C57BL/6J (Jax, from Jackson Laboratories) and C57BL/6NTac (Taconic Biosciences) substrains spanning postnatal days (P)16, P18, P21, P25 and P30. Taconic male and female mice show an earlier onset of persistent auditory fear memory and spontaneous recovery (females only) compared to Jax mice. Male Taconic mice also display earlier onset of renewal compared to Jax males. These data identify ontogenetic differences in fear processing among C57BL/6 mouse substrains, highlighting how individual differences can contribute to altered behavioral phenotypes in early development.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.003 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".