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Record W4417525898 · doi:10.1038/s42003-025-09372-2

Pupil size predicts exploration through critical slowing in prefrontal dynamics

2025· article· en· W4417525898 on OpenAlexafffund
Akram Shourkeshti, Mojtaba Abbaszadeh, Gabriel Marrocco, Katarzyna Jurewicz, Tirin Moore, R. Becket Ebitz

Bibliographic record

VenueCommunications Biology · 2025
Typearticle
Languageen
FieldNeuroscience
TopicNeural and Behavioral Psychology Studies
Canadian institutionsMcGill UniversityUniversité de Montréal
FundersNational Eye InstituteFonds de Recherche du Québec - SantéInstitut de Valorisation des DonnéesNatural Sciences and Engineering Research Council of CanadaJacobs FoundationCanadian Institute for Advanced ResearchU.S. Department of Health and Human Services
KeywordsPupilPupil diameterPupil sizeNeural activityPrefrontal cortexPopulationPupillary responseLuminance

Abstract

fetched live from OpenAlex

In uncertain environments, intelligent decision-makers exploit actions that have been rewarding in the past, but also explore actions that could be better. Several studies link exploration to pupil size-a peripheral correlate of neuromodulatory tone and arousal. However, pupil size may only track variables that make exploration more likely, such as volatility or reward, without directly predicting exploration or its neural bases. Here, we simultaneously measured pupil size, exploration, and neural population activity in the prefrontal cortex while two male rhesus macaques explored and exploited in a dynamic environment. We find that pupil size under constant luminance specifically predicts the onset of exploration beyond effects of reward history. Pupil size also predicts disorganized patterns of prefrontal activity at the single neuron and population levels. Our results support a model in which pupil-linked mechanisms drive exploration by pushing prefrontal dynamics through a critical tipping point.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.001
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.273
GPT teacher head0.471
Teacher spread0.198 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2025
Admission routes2
Has abstractyes

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