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Record W4417527666 · doi:10.1002/vrc2.70322

Hypospadias in a newborn puppy

2025· article· en· W4417527666 on OpenAlexaboutno aff
Catherine Ennett, M. de A. Pereira

Bibliographic record

VenueVeterinary Record Case Reports · 2025
Typearticle
Languageen
FieldMedicine
TopicUrological Disorders and Treatments
Canadian institutionsnot available
Fundersnot available
KeywordsHypospadiasPuppyPerineumPenisUrethraPreputial gland

Abstract

fetched live from OpenAlex

A 9-hour-old labrador and golden retriever cross puppy presented with an inability to urinate normally and a congenital malformation of the penis and urethra, and was euthanased on welfare grounds. On gross postmortem examination, running 3 mm caudal to the cranial prepuce and extending to the perineum was a 3.5 cm segmental incomplete fusion of the prepuce and absence of the penis, leaving a 3 mm wide gap. A focal urethral orifice of 1 mm diameter was located at the perineum (Figure 1). These findings are compatible with a diagnosis of perineal hypospadias with incomplete preputial fusion and penile agenesis. Hypospadias is a congenital malformation in which the urethra opens ventrally to its normal anatomical location, and can be further classified as glandular, coronal, penile, scrotal or perineal, depending on where the urethra is found in these cases. Often this is accompanied by incomplete fusion of the prepuce and the shortening or absence of the penis, as seen in this case. Genetic/breed and environmental aetiologies for hypospadias have been hypothesised in dogs, but have not yet been fully established.1 Catherine Ennett and Marta Pereira performed the postmortem examination. Catherine Ennett captured the images and drafted the manuscript. Marta Pereira co-drafted the manuscript. The authors declare they have no conflicts of interest. The postmortem examination was performed as a routine diagnostic case, and no further funding was received. This case was presented to the University of Nottingham Veterinary Pathology diagnostic service for postmortem examination after euthanasia on welfare grounds. The owner has consented in writing to the postmortem examination and to the use of the postmortem findings in this publication. This image (Figure 1) shows the external genitalia on gross postmortem examination of a newborn puppy after euthanasia on welfare grounds due to abnormal urination. What is the most likely diagnosis? 1) Urethrorectal fistula 2) Hypospadias 3) Anorchism 4) Paraphimosis 2) Hypospadias.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Case report · Consensus signal: Case report
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.242
Threshold uncertainty score0.492

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.032
GPT teacher head0.318
Teacher spread0.287 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designCase report
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

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