Bibliographic record
Abstract
Whether hydrogen sulfide (H2S) plays a part in the regulation of visceral smooth muscle contractility is not yet known. However, a growing body of evidence suggests this to be the case. For example, cystathione γ-lyase (CSE) occurs in the ileum whereas exogenous H2S relaxes gastrointestinal, urogenital, and uterine smooth muscle preparations at concentrations similar to those found naturally occurring in rat and human blood. The mechanism of the smooth muscle relaxant effect of H2S is also unclear. Although an effect of this gasotransmitter on visceral smooth muscle K+-adenosine triphosphate channels (i.e., similar to what occurs in vascular smooth muscle) cannot be excluded at this stage, the inability of glibenclamide pretreatment to inhibit relaxation of guinea pig ileum to H2S suggests that alternative mechanisms may occur at the cellular level. Recent work suggests that H2S synergizes with nitric oxide in relaxing guinea pig ileum. Interestingly, the possibility that endogenous H2S may regulate ileal smooth muscle contractility, at least in vitro, is suggested by the use of propargylglycine and β3-cyanoalanine, which inhibit CSE enzyme activity and thereby effectively remove the endogenous H2S-mediated smooth muscle relaxant effect. Both drugs cause a time- and dose-dependent augmentation of the response of guinea pig ileum to electrical (field) stimulation. Evaluation of the effect of H2S on visceral smooth muscle is still very much in its infancy, and many more experiments are required before the physiological, pathophysiological, and perhaps even the clinical significance of this gas can be fully determined.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".