Heme Oxygenase‐1 Attenuates Isoproterenol‐induced Cardiac Hypertrophy in vivo
Bibliographic record
Abstract
Heme oxygenase‐1 (HO‐1) is an oxidative stress responsive gene that is implicated in protection against many pathophysiological processes including ischemia reperfusion injury and heart failure. As elevated activity of the sympathetic nerve system is a common feature of heart failure, the present study was designed to investigate the role of HO‐1 in cardiac hypertrophy during chronic β‐adrenoceptor stimulation. Isoproterenol was administered to wild type, non‐transgenic or transgenic cardiac specific HO‐1 overexpressing (α‐MHC‐HO‐1) FVB mice for 15 or 30 days at a rate of 30 μg/g/day. Chronic isoproterenol infusion caused a significant increase in left ventricular cardiac mass in the non‐transgenic but not transgenic mice (mg/g heart to body weight ratio: sham 4.9 ± 0.4, isoproterenol 6.4 ± 1.3; and sham 5.9 ± 0.7, isoproterenol 5.8 ± 0.5 for non‐transgenic and transgenic mice, respectively). Isoproterenol‐induced cardiac hypertrophy was accompanied by an increase in ventricular end diastolic pressure (P < 0.05), myocardial fibrosis and superoxide generation as measured by NADH oxidase activity. These data suggest that HO‐1 alleviates oxidative stress and cardiac hypertrophy under excessive β‐adrenergic stimulation, and that overexpression of HO‐1 is beneficial for sympatho‐excitatory cardiac hypertrophy and failure in mice. This work was supported by the Heart and Stroke Foundation of Canada.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".