Dysregulated neutrophil function promotes chronic intestinal parasite infection (P3068)
Bibliographic record
Abstract
Abstract Clearance of intestinal helminth infection and acquired resistance is dependent on an appropriate type-2 immune response. In the Trichuris muris (Tm) infection model in mice, resistant strains expel worms via a Th2 cell-mediated response whereas susceptible strains produce high levels of Th1 cell-associated cytokines and become chronically infected. Myeloid-cell specific deletion of Ship1 (SHIPΔLysM) in a normally resistant mouse strain (C57Bl6) results in chronic infection because of inappropriate production of IL12 in the intestine and mesenteric lymph nodes (mLNs) in Tm-infected mice. Although Ship1-deficient macrophages overproduce IL12 in vitro and in vivo and thus likely contribute to the Tm-susceptibility of SHIPΔLysM mice; surprisingly, deletion of Ship1 in the neutrophil lineage alone (SHIPΔPMN) is sufficient to render a resistant strain susceptible. Chronic worm burden in SHIPΔPMN mice is associated with elevated IL12, IFNγ and decreased IL13 production in the intestine and mLNs. These data suggest that regulation of neutrophil function by Ship1 is required for parasite clearance in response to Tm infection. Although neutrophils are rapidly recruited to the intestine following Tm infection, neutrophils are not required for clearance of parasites. However, our results suggest that dysregulated neutrophil activity can contribute to chronic parasitic infection.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".