Endogenous hydrogen peroxide is vasoactive in mesenteric arteries of spontaneously hypertensive rat
Bibliographic record
Abstract
Hydrogen peroxide (H 2 O 2 ) is an endogenous endothelium‐dependent dilator in resistance vessels; however, a role for H 2 O 2 in the mesenteric vessels of the spontaneously hypertensive rat (SHR) has not been established. Mesenteric arteries were excised from SHR and normotensive (WKY) rats and myography was performed. Vessels were incubated with 3μM of the β‐blocker propranolol, pre‐contracted with norepinephrine, and cumulative dose‐response curves for acetylcholine (Ach) were conducted. Maximal dilation to Ach was impaired in SHR compared to WKY (76±4% vs 97±1%, p<0.05). Co‐incubation with the nitric oxide synthase inhibitor N ω ‐nitro‐L‐arginine (L‐NAME, 0.3mM) and the cyclooxygenase inhibitor indomethacin (INDO, 5μM) reduced dilation in SHR (52±6%, p<0.05). Co‐incubation with L‐NAME, INDO, and the H 2 O 2 scavenger catalase (CAT, 860U/mL) caused a further reduction in SHR dilation (32±3%, p<0.05). Incubation with CAT alone caused improved dilation (92±12%, p<0.05) while incubation with the superoxide dismutase mimetic 4‐hydroxy‐TEMPO (1mM) reduced dilation (59±7%, p=0.05) in SHR. WKY dilation was not altered by any treatment. Thus, in the presence of nitric oxide and prostaglandins, H 2 O 2 acts as a constrictor; however, in the absence of nitric oxide and prostaglandins, H 2 O 2 acts as a dilator in SHR mesenteric arteries. Funding: NSERC/Heart and Stroke Foundation of Ontario
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".