Transfection and Transcription of Genes in Developing Thymocytes
Bibliographic record
Abstract
Thymocyte development is characterized by the stage-specific expression of CD4 and CD8 surface molecules (1). The earliest thymic immigrants, arriving from the fetal liver or bone marrow, lack CD4 and CD8 expression (CD4− CD8−, double negative (DN) (2). This population can be further subdivided into four discrete subsets defined by the differential expression of CD117 (stem cell factor, SCF, receptor; c-kit) and CD25 (IL-2Rα) (3). The earliest population is identified as CD117+ CD25−, and contains precursors for T, B, and natural killer (NK) lymphocyte lineages. Induction of CD25 expression on progenitor CD117+ thymocytes characterizes commitment to the T cell lineage (4). The CD117+ CD25+ stage is also accompanied by an increased rate of cellular proliferation (5). Loss of CD117 expression correlates with the initiation of TCR-β gene rearrangement (6). Only thymocytes that successfully rearrange their TCR-β locus expand and differentiate to the next stage; this important developmental checkpoint is known as β-selection (7,8). Expression of CD25 ends with the generation of a functionally rearranged TCR-β chain, which together with the pre-TCR-α (pre-Tβ) chain forms the pre-TCR complex (9).
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".