Basaloid Squamous Cell Carcinoma of the Nasal Septum Presenting as a Primary Cutaneous Lesion
Bibliographic record
Abstract
Background: Basaloid squamous cell carcinoma is a rare aggressive variant of squamous cell carcinoma, with a predilection for the head and neck region. There are only two case reports in the literature documenting a nasal cavity squamous cell carcinoma presenting as a primary cutaneous lesion. Objective: We report a rare case of nasal cavity basaloid squamous cell carcinoma presenting initially as a nasal bridge mass. Two initial biopsies revealed features consistent with basal cell carcinoma and basosquamous cell carcinoma, respectively. Result: Final surgical pathology showed extensive invasive squamous cell carcinoma with basaloid differentiation arising from the nasal septal mucosa with extension to the overlying skin. The clinicopathologic features were interpreted as basaloid squamous cell carcinoma. Conclusion: We discuss the difficulties in pathologic diagnosis of this condition given its varied phenotypical expression. As well, this case emphasizes the necessity for diagnostic vigilance when assessing a primary cutaneous lesion as it may be a rare presentation of an underlying malignancy extending to the skin. Contexte: Le carcinome squameux basaloïde est une variante rare et très maligne du carcinome squameux, qui touche le plus souvent la tête et le cou. La documentation médicale ne compte que deux exposés de cas sur le carcinome squameux de la cavité nasale se présentant sous forme de lésion cutanée primitive. Objectif: Nous faisons état ici d'un rare cas de carcinome squameux basaloïde de la cavité nasale, se présentant au départ comme une masse dans la voûte des fosses nasales. Deux biopsies ont été pratiquées au départ, et les résultats se sont montrés compatibles avec les caractéristiques du carcinome basocellulaire et du carcinome basospinocellulaire, respectivement. Résultat: L'examen histopathologique définitif de la pièce opératoire a révélé la présence d'un carcinome squameux invasif, étendu, accompagnée d'une différenciation basaloïde prenant naissance dans la muqueuse de la cloison nasale et se prolongeant jusqu'à la peau sus-jacente. Les manifestations clinicopathologiques laissaient croire à un carcinome squameux basaloïde. Conclusion: Il sera question ici des difficultés que pose le diagnostic histopathologique de cette affection compte tenu de son expression phénotypique variée. De plus, le cas met en évidence la nécessité de faire preuve de vigilance dans l'établissement du diagnostic lorsqu'on évalue des lésions cutanées primitives étant donné que celles-ci peuvent être une manifestation rare d'une tumeur maligne sous-jacente, qui s'étend jusqu'à la peau.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".