WISE‐2005: Adrenergic responses to 60 days of 6o head‐down bed‐rest (BR) in women with exercise counter‐measures
Bibliographic record
Abstract
Women are especially susceptible to orthostatic intolerance on return from space or after BR. Before and after 2 doses of isoproterenol (ISO) or norepinephrine (NOR) MAP, HR, cardiac output (Q), stroke volume (SV), and total peripheral resistance (TPR) were measured in 8 controls and 8 women with flywheel and lower body negative pressure treadmill exercise (EX). Pre‐BR, ISO2 caused: higher HR, higher SV, higher Q, and lower TPR. NOR2 caused: lower SV, lower Q, higher TPR and higher MAP. Post‐BR controls show higher baseline HR (64.9 ± 2.3 to 72.5 ± 4.8 bpm) and no increase in MAP due to NOR1. Post‐BR EX show no increase of baseline HR, higher baseline TPR (18.0 ± 2.1 to 20.2 ± 2.8 mmHg/mL/min), reduced baseline Q (5.5 ± 0.5 mL/min to 4.5 ± 0.5 mL/min), reduced Q with ISO2 (Pre: 8.6 ± 0.9 mL/min; Post: 7.5 ± 0.8 mL/min), augmented TPR with NOR1 (Pre: 19.4 ± 2.2 mmHg; Post: 23.7 ± 3.3 mmHg). Controls show decreased peripheral and increased cardiac sensitivity of adrenergic receptors. EX show increased peripheral sensitivity without cardiac augmentation. We conclude that exercise is cardioprotective after exposure to 60‐day BR (CSA, NASA, ESA & CNES).
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".