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Record W5984741

A refined multisite fungal protein localizer

2008· article· en· W5984741 on OpenAlex
Michel Nathan, Gregory Butler

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueInternational conference on Artificial intelligence and applications · 2008
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMachine Learning in Bioinformatics
Canadian institutionsConcordia University
Fundersnot available
KeywordsSubcellular localizationClassifier (UML)Protein subcellular localization predictionComputer scienceArtificial intelligenceComputational biologyPattern recognition (psychology)Data miningBiologyCytoplasmBiochemistryGene
DOInot available

Abstract

fetched live from OpenAlex

In a previous work, we built a classifier that used a decision tree to predict fungal protein localization based on physiochemical properties of proteins. 178 features selected from proteins compositional properties, functional motifs and signal sequences were studied for their effect on subcellular localization. That work resulted in a localizer that would successfully predict some of the reported localizations in 64% of the cases and all the reported localizations in 49% of the cases. Here, we improve on the results of the mentioned work by streamlining the classes of protein features used. Considering various modes of intra-cellular protein movement and the requirements for such transport, we establish a list of features that would have direct impact on the recognition of the proteins by the transport machinery of the cell. We shall detect the occurrence of such features in fungal proteins and use them as potential determinants of subcellular localization. The system rebuilt based on 980 of such features is validated using a 5-fold cross validation and results in a success rate of 87% for predicting some and 77% for predicting all the reported localization sites of 3 fungal species for which annotations on subcellular localization were available.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.744
Threshold uncertainty score0.458

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.062
GPT teacher head0.329
Teacher spread0.268 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it