Posterior Cingulate Gyrus Associated with Cognitive-inhibition in Depressed Patients At-risk for Suicide
Bibliographic record
Abstract
Suicidal behavior results from a complex interplay between stressful events and vulnerability factors, including neurocognitive alterations. Deficits in cognitive inhibition have previously been found in suicide attempters. Here, we examined the neural basis of these deficits in patients at-risk for suicide. Functional magnetic resonance imaging was used to measure brain activation in 25 middle-aged depressed yet non-medicated suicide attempters (SA), 22 depressed patient controls with no personal or first-degree family history of suicidal behaviour (PC), and 27 healthy controls (HC) during the Go/No-Go response inhibition task. In whole brain exploration of No-Go versus Go inhibition contrast, SA show elevated activities in posterior cingulate gyrus compared to HC (Cluster FWE = 0.022). Further exploration of each individual condition against baseline (e.g. No-Go versus Baseline or Go versus Baseline) suggest this regional differences are mainly due to No-Go baseline comparison within each groups: namely, HC show a large reduced activities during No-Go blocks while PC and SA failed to show similar reductions comparing to baseline. SA showed unique differentiated patterns of neural activity during Go-No-Go response inhibition differ from HC and PC mostly involving posterior cingulate gyrus. These findings indicate that suicide attempts during middle-aged are associated with abnormal activity in response inhibition neural circuitry. Download : Download full-size image
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".