Rigidity and HyperCKemia as Presenting Signs of Hashimoto's Encephalopathy
Bibliographic record
Abstract
Hashimoto's encephalopathy (He) is a rare and poorly understood syndrome affecting the central nervous system.Because of association with Hashimoto's thyroiditis and high serum antithyroid antibody titers, it is a disease of presumably autoimmune origin. 1 The exact nature of the immune response in He is still unclear.The clinical picture may include cognitive impairment, psychiatric manifestations, impairment of consciousness, seizures, myoclonus, tremor, and stroke-like episodes.2 It is generally accepted that the syndrome is recognized when the following conditions are met: encephalopathy manifesting as cognitive dysfunction, impairment of consciousness, seizure, or neuropsychiatric disorder; elevated serum levels of antithyroid antibodies; good response to glucocorticoid treatment; exclusion of infectious, vascular, metabolic, toxic, or neoplastic etiologies.3 In the case presented, a patient presented initially with acute progressive rigidity and hyperCKemia but was ultimately diagnosed with He.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.008 | 0.005 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".