Epigenetic Investigations in the Family Intervention for Empowerment through Reading and Education (FIERCE) Study
Bibliographic record
Abstract
This project is specifically for the DNA methylation and genotyping component of the FIERCE study of Syrian mother and child pairs of refugees in Jordan taking part in the We Love Reading (WLR) intervention. The current study will investigate whether and how the effect of the We Love Reading (WLR) intervention program gets “under the skin” of refugee children and their mothers in Jordan. To this end, we will examine differences in genetic and epigenetic markers (specifically, DNA methylation) between the intervention and control groups. Using an epigenetic biomarker of biological aging as well as an exploratory epigenome-wide approach, we will identify epigenetic changes associated with WLR. Post-hoc analysis will be conducted to scrutinize how biological findings may associate with underlying genotypic differences, as well as map onto children’s socioemotional outcomes and maternal mental health and wellbeing. We will further examine the role that family dynamics play in these aforementioned relationships and how family dynamics (specifically parenting and mental health) are reflected in DNA methylation as well.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.006 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".