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Record W6887867881 · doi:10.17863/cam.6739

Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3.

2016· article· en· W6887867881 on OpenAlexfundno aff

Bibliographic record

VenueApollo (University of Cambridge) · 2016
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBRCA gene mutations in cancer
Canadian institutionsnot available
FundersJonsson Comprehensive Cancer CenterNational Center for Advancing Translational SciencesEuropean Regional Development Fundlékařská fakulta Univerzity KarlovyUniversity of California, San FranciscoNational Institutes of HealthKerry Group Kuok FoundationFreistaat SachsenNational Cancer InstituteLiga Portuguesa Contra o CancroFox Chase Cancer CenterMinistero dello Sviluppo EconomicoMedical Research CouncilUppsala UniversitetInstitut National Du CancerDeutsche KrebshilfeSahlgrenska UniversitetssjukhusetUniversità degli Studi di FirenzeOvarian Cancer Research FundLandspítali HáskólasjúkrahúsHungarian Scientific Research FundNational Health and Medical Research CouncilFundación CellexFisher Center for Alzheimer's Research FoundationJewish General HospitalLunds UniversitetNederlandse Organisatie voor Wetenschappelijk OnderzoekMinistero della SaluteGeneralitat de CatalunyaAmerican Cancer SocietyFonds Wetenschappelijk OnderzoekCancer Center, University of KansasCancerfondenCancer Association of South AfricaNational Breast Cancer FoundationEuropean CommissionNational Institute for Health and Care ResearchKWF KankerbestrijdingCancer Research UKGovernment of CanadaFondation du cancer du sein du QuébecMemorial Sloan-Kettering Cancer CenterNRG OncologyIsrael Cancer AssociationInstitut Català de la SalutUniversity of PennsylvaniaMinistère du Développement Économique, de l’Innovation et de l’ExportationAssociazione Italiana per la Ricerca sul CancroGenome CanadaClalit Health ServicesDeutsches KrebsforschungszentrumBreast Cancer Research FoundationMcGill UniversityUniverzita Karlova v PrazeNIH Office of the DirectorMinistério da Ciência, Tecnologia e InovaçãoDr. Ralph and Marian Falk Medical Research TrustKansas Bioscience AuthorityGeorgetown UniversitySusan G. Komen for the CureCanadian Institutes of Health ResearchGeneral Secretariat for Research and TechnologyBeth Israel Deaconess Medical CenterInstituto de Salud Carlos IIIOhio State UniversityCancer AustraliaFondation ARC pour la Recherche sur le CancerIstituto Oncologico VenetoRoyal Marsden NHS Foundation TrustEuropean Social FundUniversity of ChicagoLietuvos Mokslo Taryba
KeywordsBreast cancerSingle-nucleotide polymorphismAlleleLocus (genetics)Genetic associationSNPGeneGenome-wide association studyGenetic variation

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.009

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.005
GPT teacher head0.204
Teacher spread0.199 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2016
Admission routes1
Has abstractno

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